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Academic Research into Down Syndrome

MedWorm: Down's Syndrome

• Noninvasive detection of fetal trisomy 21: systematic review and report of quality and outcomes of diagnostic accuracy studies performed between 1997 and 2012
• The Heroic Father
• Short‐term treatment with the GABAA receptor antagonist pentylenetetrazole produces a sustained pro‐cognitive benefit in a mouse model of Down's syndrome
• Deficits in human Down syndrome neurons [Neuroscience]
• Upregulation of RCAN1 causes Down syndrome-like immune dysfunction
• Non-invasive blood test can detect Down's syndrome
• New Down Syndrome Test Is More Reliable, Say Researchers
• Blood Test Works for Detecting Down Syndrome (CME/CE)
• VIDEO: New Down's syndrome screening developed
• New Down's syndrome blood test may be less-invasive option
• Down's Syndrome Testing Can Be Earlier And More Reliable Say Researchers
• Down's syndrome blood test that can reliably detect if an unborn baby has condition to go on trial
• New Down’s syndrome blood test 'more reliable'
• Researchers Target An Aspect Of Down Syndrome
• New Down's syndrome blood test more reliable, say researchers
• New Down's Syndrome blood test to go on trial
• Early Down's test 'more sensitive'
• Non-invasive first trimester blood test reliably detects Down's syndrome
• Aerobic training improved low‐grade inflammation in obese women with intellectual disability
• Global DNA Hypermethylation in Down Syndrome Placenta
• Computerized Memory Training Leads to Sustained Improvement in Visuospatial Short-Term Memory Skills in Children with Down Syndrome
• Pregnancy‐associated plasma protein A levels and neonatal complications in post‐date pregnancies
• [First-trimester cystic hygroma: Prenatal diagnosis and fetal outcome.]
• Cognitive Flexibility Among Individuals With Down Syndrome: Assessing the Influence of Verbal and Nonverbal Abilities
• Triple X Egyptian woman and a Down's syndrome offspring
• Symptomatic Atlantoaxial Instability in an Adolescent with Trisomy 21 (Down's syndrome)
• [Case Report] Infantile eczema caused by formula milk
• Anti-Inflammatory Effect of Exercise, via Reduced Leptin Levels, in Obese Women With Down Syndrome.
• Supported housing for people with Down's syndrome
• Fay Bleasdale describes how she fell into a black hole when her son was diagnosed with Down's Syndrome
• Age independent first trimester screening for Down syndrome: improvement in test performance
• Learning to read in Williams syndrome and Down syndrome: syndrome‐specific precursors and developmental trajectories
• Down Syndrome Neurons Grown From Stem Cells Show Signature Problems
• Neurons Grown From Stem Cells Show Signature Problems In Down Syndrome
• Surgical Strategy for Atrioventricular Septal Defect and Tetralogy of Fallot or Double-Outlet Right Ventricle [ORIGINAL ARTICLES: CONGENITAL HEART SURGERY]
• Brain cells give insight into Down's
• Isolated Fetal Pyelectasis and the Risk of Down Syndrome: A Meta-Analysis.
• Isolated Fetal Pyelectasis and the Risk of Down Syndrome: A Meta‐Analysis
• Down syndrome neurons grown from stem cells show signature problems
• Comparative Analysis between Three Methods of Bone Estimating Age in Individuals with Down Syndrome by Mode of the Hand and Wrist Ray.
• Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome
• Role of RNA splicing in mediating lineage-specific expression of the von Willebrand factor gene in the endothelium
• Evaluation of functional skills and self care of Down's syndrome people included in therapeutic workshop
• Improving manual skills in persons with disabilities (PWD) through a multimodal assistance system.
• Moyamoya syndrome in a Malaysian child with Down syndrome
• Allergy and acute leukaemia in children with Down syndrome: a population study. Report from the Mexican inter-institutional group for the identification of the causes of childhood leukaemia
• Family demands, social support and family functioning in Taiwanese families rearing children with Down syndrome
• Molecular Detection of Trisomy 21 by Bicolor Competitive Fluorescent PCR
• The role of noninvasive prenatal testing as a diagnostic versus a screening tool ‐ a cost‐effectiveness analysis
• Maternal cfDNA screening for Down syndrome – a cost sensitivity analysis
• Quality of life among Malaysian mothers with a child with Down syndrome
• Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting
• How'd that work: Do pesticides cause birth defects?
• Yoga With Down Syndrome: Sarah Shaffer's Story
• Parents Help Detect Sleep Problems In Children With Down Syndrome
• The influence of image setting on intracranial translucency measurement by manual and semi‐automated system
• Sodium Valproate Induced Tremor in a Patient with Epilepsy and Down's Syndrome.
• Why All The Buzz About Gluten-Free
• Effectiveness of supportive care measures to reduce infections in pediatric AML: a report from the Children's Oncology Group
• [Anesthesiological considerations for patients with trisomy 21 (Down syndrome)].
• Universal tight correlation of codon bias and pool of RNA codons (codonome): The genome is optimized to allow any distribution of gene expression values in the transcriptome from bacteria to humans.
• Nuchal translucency measurement: are qualitative and quantitative quality control processes related?
• Can individuals with Down syndrome improve their grammar?
• Age independent first‐trimester screening for Down syndrome: improvement in test performance
• Foregut duplication cyst associated with esophageal atresia and tracheoesophageal fistula: A case report and literature review
• Self-advocate helps all
• Taking each day as it comes: staff experiences of supporting people with Down syndrome and Alzheimer's disease in group homes
• Double-Orifice Left Atrioventricular Valve in Patients With Atrioventricular Septal Defect With and Without Down Syndrome [CORRESPONDENCE]
• Utilizing High‐Fidelity Crucial Conversation Simulation in Genetic Counseling Training
• Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome.
• Preventable visual impairment in children 
with nonprofound intellectual disability.
• Performance of Down syndrome subjects during a coincident timing task
• Nuchal translucency measurement: are qualitative and quantitative quality‐control processes related?
• Proposed remedies for some developmental disorders
• Nardilysin in human brain diseases: both friend and foe.
• The Damaging Effect Of Cholesterol On The Brain And On Blood Vessels
• Sleep disorders in children with Down syndrome
• The calcineurin-NFAT pathway negatively regulates megakaryopoiesis
• Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome
• Outcomes of treatment for relapsed acute lymphoblastic leukaemia in children with Down syndrome
• Noninvasive prenatal testing creates an opportunity for antenatal treatment of down syndrome
• Evidence that PICALM affects age at onset of Alzheimer's dementia in Down syndrome.
• The impact of maternal plasma DNA fetal fraction on next generation sequencing tests for common fetal aneuploidies
• Cholesterol increases risk of Alzheimer's and heart disease
• Memory drug trialled in people with Down's syndrome
• 12 minute consultation: an evidence‐based approach to the management of a child with speech and language delay
• Deaths Among Children, Adolescents, and Young Adults with Down Syndrome
• What is the relevance of Ikaros gene deletions as prognostic marker in pediatric Philadelphia negative B-cell precursor acute lymphoblastic leukemia?
• Memory drug trialled in people with Down's syndrome
• Attitudes among Danes toward termination of pregnancy for social reasons and fetal abnormality
• Disrupted small-world brain network in children with Down Syndrome.
• Impact of introducing a national policy for prenatal Down syndrome screening on the diagnostic invasive procedure rate in England
• Observatory: Protein in Alzheimer’s Linked to Down Syndrome
• A commentary on: Overexpression of Dyrk1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome.
• New Questions on Cutting-Edge Prenatal Tests
• Sorting receptors at Down's syndrome synapses
• Teen with Down syndrome climbs Everest
• Author's response regarding “MeDIP‐qPCR approach for non‐invasive prenatal diagnosis of Down syndrome: accuracy and reproducibility”
• Surgical outcome of congenital heart disease in Down's syndrome
• Isolated cervical spinal canal stenosis at C-1 in the pediatric population and in Williams syndrome.
• New insights into the pathobiology of Down syndrome – hyaluronan synthase‐2 overexpression is regulated by collagen VI α2 chain
• Down Syndrome Trial May Hold Key To Learning
• Women and their partners' preferences for Down's syndrome screening tests: a discrete choice experiment
• Discordant results between fetal karyotyping and non‐invasive prenatal testing by maternal plasma sequencing in a case of uniparental disomy 21 due to trisomic rescue
• Down Syndrome kids' dreams
• The Molecular Roots Of Down Syndrome Unraveled
• Maternal serum placental growth factor and α‐fetoprotein testing in first trimester screening for Down syndrome
• Significant modifications of the salivary proteome potentially associated with complications of Down syndrome revealed by top-down proteomics.
• PLAC4 is upregulated in severe early onset preeclampsia and upregulated with syncytialisation but not hypoxia
• Corneal thickness measured by Scheimpflug imaging in children with Down syndrome
• Down's syndrome brain protein loss
• Sanford-Burnham researchers unravel molecular roots of Down syndrome
• Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome
• Single and mixed-species trypanosome and microsporidia infections elicit distinct, ephemeral cellular and humoral immune responses in honey bees.
• Down Syndrome doesn't change dreams
• Celebrate Down Syndrome Day!
• Survey of second‐trimester maternal serum screening in Japan
• Blood Protein Could Detect Cardiovascular Events
• Chemotherapy for transient myeloproliferative disorder in a premature infant with Down syndrome
• The impact of maternal weight discrepancies on prenatal screening results for down syndrome
• The triple challenges associated with age‐related comorbidities in Down syndrome
• Blood Protein Able To Detect Higher Risk Of Cardiovascular Events In People With Chest Pain Originating From Heart Disease
• First‐trimester Down syndrome screening in renal‐transplanted pregnant women: a model for adjusting the false‐positives rates
• Prevalence of ocular abnormalities in adults with Down syndrome in Hong Kong
• Down Syndrome: Screening For Breathing Problems To Stop Unnecessary Suffering
• Trisomy 21 and facial developmental instability
• Cumulative sum plots and retrospective parameters in first‐trimester ductus venosus quality assurance
• Oxidative burst intensity of peripheral phagocytic cells and periodontitis in Down syndrome
• Short‐term treatment with the GABAA antagonist pentylenetetrazole produces a sustained procognitive benefit in a mouse model of Down's syndrome.
• Feasibility of using plasma rather than serum in first and second trimester multiple marker Down's syndrome screening
• New therapies for treating Down syndrome require quality of life measurement
• The significance of aspects of screening for obstructive sleep apnoea in children with Down syndrome
• Prenatal characteristics of false negative cases from first‐trimester screening of Down syndrome (trisomy 21)
• Microarray versus karyotyping for antenatal diagnosis and after stillbirth
• A rare de novo duplication of chromosome 21q22.12¿¿¿q22.3 with other concomitant deletion and duplication of small fragments in 21q associated with Down syndrome: Prenatal diagnosis, molecular cytogenetic characterization
• Evaluation of C677T polymorphism of the methylenetetra hydrofolate reductase gene and its association with levels of serum homocysteine, folate, and vitamin B12 as maternal risk factors for Down syndrome
• Outcome of Transplantation for Acute Myelogenous Leukemia in Children with Down Syndrome
• Helping Speech and Stuttering in Children with Down syndrome
• Pulmonary Vein Stenosis with Down Syndrome: A Rare and Frequently Fatal Cause of Pulmonary Hypertension in Infants and Children
• Role of second-trimester ultrasound in screening for Down syndrome.
• Interstitial lung disease and profound hypoxaemia in a severely-malnourished child with very severe pneumonia and potential lymph-node tuberculosis: an uncommon but serious co-morbidity.
• Hemodialysis treatment on an adult patient with down syndrome associated with ectopic right kidney chronic obstructive nephropathy and secondary amyloidosis.
• Go For The Glory Quiz: Down Syndrome Complications, Infant Shock, Stroke Survivors, Doxycycline Adverse Events
• Higher Order Aberrations in Children with Down Syndrome [Visual Psychophysics and Physiological Optics]
• Blast cell deficiency of CD11a as a marker of acute megakaryoblastic leukemia and transient myeloproliferative disease in children with and without Down syndrome
• Addressing Stuttering In Down Syndrome
• 26-year-old with Down Syndrome asphyxiated while resisting cops over movie ticket
• Giving a voice to kids with Down syndrome
• Home Education and Children with Down Syndrome. The Primary Years
• What Causes Constipation?

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